epitope corresponding to amino acids 1-70 mapping at the N-terminus of Calnexin of human origin
recommended for detection of Calnexin of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine, bovine and porcine
Calnexin Background Information Calnexin and Calregulin (also called calreticulin) are calcium-binding proteins that are localized to the endoplasmic reticulum, Calnexin to the membrane and Calregulin to the lumen. Calnexin is a type I membrane protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may play a role in assisting with protein assembly and in retaining unassembled protein subunits in the endoplasmic reticulum. Calregulin has both low- and high-affinity calcium-binding sites. Neither Calnexin nor Calregulin contains the calcium-binding “E-F hand” motif found in calmodulins. Calnexin and Calregulin are important for the maturation of glycoproteins in the endoplasmic reticulum and appear to bind many of the same proteins.
Calnexin (H-70) Product Citations
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Calnexin (H-70)
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Calnexin (H-70): sc-11397. Western blot analysis of Calnexin expression in A-431 (A) and NIH/3T3 (B) whole cell lysates.
Calnexin (H-70): sc-11397. Western blot analysis of Calnexin expression in non-transfected 293T: sc-117752 (A), human Calnexin transfected 293T: sc-170477 (B) and HeLa (C) whole cell lysates.
