epitope corresponding to amino acids 303-464 mapping near the C-terminus of glypican-3 of human origin
recommended for detection of glypican-3 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
glypican-3 Background Information Glypican-3 (GPC3) is an integral membrane protein that is mutated in the Simpson-Golabi-Behmel syndrome (SGBS). SGBS is characterized by pre- and post-natal overgrowth and is a recessive X-linked condition. Glypican-3, also designated OCI-5 in rat, is a member of the glypican family of heparan sulfate proteoglycans, which attach to the cell membrane via a glycosyl-phosphatidyl-inositol (GPI) anchor. Expression of glypican-3 is detected in embryonic mesodermal lung, liver and kidney tissues. Glypican-3 is thought to regulate tissue and organ growth through interactions with growth factors such as insulin-like growth factor II (IGF-II) or fibroblast growth factor 2 (FGF-2). Glypican-3 may be downregulated by various means, including promoter hypermethylation or the repression of specific transcription factors.
glypican-3 (H-162) Product Citations
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glypican-3 (H-162)
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glypican-3 (H-162): sc-11395. Western blot analysis of human recombinant glypican-3 fusion protein.
glypican-3 (H-162): sc-11395. Western blot analysis of glypican-3 expression in Hep G2 whole cell lysate.
glypican-3 (H-162): sc-11395. Immunofluorescence staining of methanol-fixed Hep G2 cells showing membrane localization.
