epitope mapping within an N-terminal cytoplasmic domain of ECEL1 of human origin
recommended for detection of ECEL1 (also designated XCE or DINE) of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine, porcine and avian
ECEL1 Background Information ECEL1 (endothelin-converting enzyme-like 1, also designated XCE and DINE, damage-induced neuronal endopeptidase) is a member of the family of cell-surface zinc metallo-peptidases (1,2,6,7). This family of metalloproteases includes endothelin-converting enzyme (ECE) and neutral endopeptidase (NEP) (3-5). These peptidases are involved in the post-secretory processing and metabolism of neuropeptides and peptide hormones (3). Following neuronal damage, proteolytic activity of ECEL1 activates antioxidant enzymes suggesting a mechanism for how injured neurons protect themselves against death (2). Glycosylated ECEL1 is predominantly expressed in the central nervous system, including the spinal cord and medulla (6,7).
ECEL1 (N-20)
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ECEL1 (N-20): sc-11338. Western blot analysis of ECEL1 expression in non-transfected: sc-117752 (A) and human ECEL1 transfected: sc-116127 (B) 293T whole cell lysates.
