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Topo IIIβ-1 (E-13) Antibody: sc-11266 |
| Datasheet |
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- goat polyclonal IgG, 200 µg/ml
- epitope mapping within an internal region of Topo IIIβ-1 of human origin
- recommended for detection of DNA Topoisomerase IIIβ-1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
- blocking peptide, sc-11266 P
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Ordering Information
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
TOP3B |
8940 |
22q11.22 |
NM_003935 |
O95985
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603582 |
| Mouse |
Top3b |
21976 |
16 A3 |
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Q9Z321
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N/A |
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Topo IIIβ-1 Background Information
DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA by transiently breaking and rejoining DNA strands. Although DNA topoisomerase I (Topo I) and Topo II relax both positive and negative supercoils, Topo III relaxes only negative supercoils. Topo IIIå exists as a long and a short isoform, which are produced by alternative splicing. Topo IIIå, which localizes to the nucleolus, is constitutively expressed and remains at high levels throughout the cell cycle in HL-60 cells. Topo III∫ exists as three isoforms, ∫-1, ∫-2 and ∫-3, also produced by alternative splicing. Topo III∫-1 is expressed in testis, heart, and skeletal muscle, whereas Topo III∫-2 is expressed in thymus, kidney and pancreas. |
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Topo IIIβ-1 (E-13)
Click on image to enlarge
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Topo IIIβ-1 (E-13): sc-11266. Western blot analysis of Topo IIIβ expression in non-transfected: sc-117752 (A) and mouse Topo IIIβ transfected: sc-124216 (B) 293T whole cell lysates. Topo IIIβ-1 (E-13): sc-11266. Western blot analysis of Topo IIIβ-1 expression in IMR-32 nuclear extract (A), mouse testis tissue extract (B) and K-562 whole cell lysate (C).
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