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Topo IIIα (N-20) Antibody: sc-11257 |
| Datasheet |
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- goat polyclonal IgG, 200 µg/ml
- epitope mapping at the N-terminus of Topo IIIα of human origin
- recommended for detection of DNA Topoisomerase IIIα long form of human origin by WB, IP, IF and ELISA
- blocking peptide, sc-11257 P
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Ordering Information
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
TOP3A |
7156 |
17p11.2 |
NM_004618 |
Q13472
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601243 |
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Topo IIIα Background Information
DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA by transiently breaking and rejoining DNA strands. Although DNA topoisomerase I (Topo I) and Topo II relax both positive and negative supercoils, Topo III relaxes only negative supercoils. Topo IIIå exists as a long and a short isoform, which are produced by alternative splicing. Topo IIIå, which localizes to the nucleolus, is constitutively expressed and remains at high levels throughout the cell cycle in HL-60 cells. Topo III∫ exists as three isoforms, ∫-1, ∫-2 and ∫-3, also produced by alternative splicing. Topo III∫-1 is expressed in testis, heart, and skeletal muscle, whereas Topo III∫-2 is expressed in thymus, kidney and pancreas. |
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Topo IIIα (N-20)
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Topo IIIα (N-20): sc-11257. Western blot analysis of Topo IIIα expression in HeLa (A) and K-562 (B) nuclear extracts.
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