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- goat polyclonal IgG, 200 µg/ml
- epitope mapping within an internal region of ASC-1 of human origin
- recommended for detection of ASC-1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
- blocking peptide, sc-11234 P
- TransCruz reagent for Gel Supershift and ChIP applications, sc-11234 X, 200 µg/0.1 ml
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Ordering Information
Recommended Support Products:
(click button of application of choice)
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
TRIP4 |
9325 |
15q22.31 |
NM_016213 |
Q15650
|
604501 |
| Mouse |
Trip4 |
56404 |
9 C |
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Q9QXN3
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N/A |
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ASC-1 Background Information
Activating signal co-integrator-1 (ASC-1), originally identified as TRIP4, is a transcriptional co-activator of nuclear receptors that associates with specific components of the RNA polymerase II complex and binds the basal transcription factors TBP and TFIIA. ASC-1 functions with the transcription integrators SRC-1 and CBP/p300 through its zinc finger motif and is dependent on their ligand-dependent transactivation domain, AF2. Endogenous ASC-1 in HeLa cells is predominantly a nuclear protein. Under conditions of serum starvation, ASC-1 localizes to the cytoplasm. However, when serum starved in the presence of ligand of coexpressed CBP or SRC-1, ASC-1 remains in the nucleus. This behavior of ASC-1 suggests that it may play an important role in establishing distinct co-activator complexes under different cellular conditions. |
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ASC-1 (K-16)
Click on image to enlarge
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ASC-1 (K-16): sc-11234. Western blot analysis of ASC-1 expression in non-transfected: sc-117752 (A) and mouse ASC-1 transfected: sc-118583 (B) 293T whole cell lysates. ASC-1 (K-16): sc-11234. Western blot analysis of ASC-1 expression in non-transfected: sc-117752 (A) and mouse ASC-1 transfected: sc-118583 (B) 293T whole cell lysates. |
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