p120 (S-19) Antibody: sc-1101

p120 Background Information
The catenins, a, b and g, are proteins which bind to the highly conserved, intra-cellular cytoplasmic tail of E-cadherin. Together, the catenin/cadherin complexes play an important role mediating cellular adhesion. a-catenin was initially described as an E-cadherin-associated protein and has been shown to associate with other members of the cadherin family, N-cadherin and P-cadherin. b-catenin associates with the cytoplasmic portion of E-cadherin which is necessary for the function of E-cadherin as an adhesion molecule. b-catenin has also been found in complexes with the tumor suppressor protein APC. g-catenin, also known as plakoglobin, binds with a-catenin and N-cadherin. A related protein, p120, exhibits sequence homology with the catenins at four discreet domains. p120 not only serves as a substrate for Src, but is also found in E-cadherin complexes containing catenins.