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p-ARK-1 Antibody (Thr 288): sc-109910

 |  Datasheet

(Based on data analysis)
  • p-ARK-1 Antibody (Thr 288) is a rabbit polyclonal IgG provided at 100 µg/ml
  • epitope corresponding to phosphorylated Thr 288 of ARK-1 of human origin
  • recommended for detection of Thr 288 phosphorylated ARK-1 of human origin and correspondingly Thr 279 phosphorylated ARK-1 of mouse origin and Thr 281 phosphorylated ARK-1 of rat origin of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
  • blocking peptide, sc-109910 P
 

See additional ARK Antibodies including ARK, ARK-1, ARK-2, ARK-3 and ARK5.

Also see ARK-1 Inhibitors for functional analysis of cellular responses to ARK-1.


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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
p-ARK-1 Antibody (Thr 288) sc-109910 100 µg/ml $279
p-ARK-1 (Thr 288) P sc-109910 P
(peptide)
 100 µg/0.5 ml $61
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human AURKA 6790 20q13.2 NM_003600, NM_198433, NM_198434, NM_198435, NM_198436, NM_198437 O14965
 603072
 

Aurora related kinase-1 (ARK-1, STK15, Aurora2, Aik1) and -2 (ARK-2, STK12, Aurora1) are centrosome-associated serine/threonine kinases that regulate centrosome separation, bipolar spindle assembly and chromosome segregation during mitosis. ARK-1 and -2 are expressed in the nucleus and localize to distinct portions of mitotic machinery such as the centrosome, spindle poles (ARK-1) and midbody (ARK-2) during mitosis. ARK-1 and -2 transcripts are present at high levels in human thymus and fetal liver. ARK-1 protein has elevated expression in colon carcinoma lines (HT-29, SNU-C2B, COLO 205, SW480, 837 and 948) and accumulates during metaphase in HeLa cells. ARK-2 protein levels are maximal during both S and G2/M phases, whereas ARK-1 protein is degraded after G2/M via the ubiquitin-proteasome pathway. ARK-2 has a unique genetic loci relative to ARK-1, suggesting that these two kinases, with oncogenic potential, have different roles in cell cycle progression.