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- goat polyclonal IgG, 200 µg/ml
- epitope mapping near the N-terminus of R2 of human origin
- recommended for detection of R2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
- blocking peptide, sc-10846 P
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Ordering InformationProduct Citations
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
RRM2 |
6241 |
2p25.1 |
NM_001034 |
P31350
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180390 |
| Mouse |
Rrm2 |
20135 |
12 A1.3 |
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P11157
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N/A |
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R2 Background Information
Ribonucleotide reductase is essential for the production and maintenance of the level of deoxyribonucleoside triphosphates (dNTPs) required for DNA synthesis. It is an enzymatic complex consisting of two nonidentical subunits, R1 and R2, which are inactive separately. R2, the smaller subunit, is localized to the cytoplasm. R2 is the limiting factor of the catalytic activity of the ribonucleotide reductase enzymatic complex. R2 expression is strictly correlated to the S-phase of the cell cycle, whereas R1 remains constant throughout all phases of the cell cycle. While R2 seems to be involved solely in the maintenance of dNTPs for DNA replication, a similar protein, p53R2, has been shown to be responsible for the production of dNTPs in response to DNA damage.
| R2 (E-16) Product Citations |
See how others have used R2 (E-16): sc-10846 antibody and or R2 (E-16) antibody conjugates.
10 total citations Loading citations.
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R2 (E-16)
Click on image to enlarge
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R2 (E-16): sc-10846. Western blot analysis of R2 expression in HeLa (A), A-431 (B) and K-562 (C) whole cell lysates.
R2 (E-16): sc-10846. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human lymphoma (A) and immunofluorescence staining of methanol-fixed HeLa cells (B) showing cytoplasmic staining.
R2 siRNA (h): sc-36338. Western blot analysis of R2 expression in non-transfected control (A) and R2 siRNA transfected (B) HeLa cells. Blot probed with R2 (E-16): sc-10846. GAPDH (FL-335): sc-25778 used as specificity and loading control. R2 (E-16): sc-10846. Western blot analysis of R2 expression in A-431 whole cell lysate.
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