epitope corresponding to amino acids 218-336 of 5-hydroxytryptamine (serotonin) receptor 1A of human origin
recommended for detection of serotonin 1A receptor (5-HT1A) of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine
SR-1A Background Information The members of the G-protein-coupled receptor family are distinguished by their slow transmitting response to ligand binding. These seven transmembrane proteins include the adrenergic, serotonin and dopamine receptors. The effect of the signaling molecule can be excitatory or inhibitory depending on the type of receptor to which it binds. b-adrenergic bound to adrenaline activates adenylyl cyclase, while a2-adrenergic receptor bound to adrenaline inhibits adenylyl cyclase. Like the a2-adrenergic receptor, serotonin receptor functions are also mediated by G proteins that inhibit the activity of adenylyl cyclase. The serotonin receptors have been classified into several categories, designated SR-1–7 (5HT1–7). Subtypes within the SR-1 group include SR-1A, -1B, -1D, -1E and -1F.
SR-1A (H-119) Product Citations
See how others have used SR-1A (H-119): sc-10801 antibody and or SR-1A (H-119) antibody conjugates.
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SR-1A (H-119)
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SR-1A (H-119): sc-10801. Western blot analysis of glycosylated and deglycosylated SR-1A expression in Saos-2 whole cell lysate.
SR-1A (H-119): sc-10801. Western blot analysis of SR-1A expression in Saos-2 (A), Daudi (B) and Raji (C) whole cell lysates.
SR-1A (H-119): sc-10801. Immunofluorescence staining of methanol-fixed HeLa cells showing membrane localization.
