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JAK3 Antibody (H-20): sc-1080

 |  Datasheet

(Based on data analysis)
  • JAK3 Antibody (H-20) is a goat polyclonal IgG provided at 200 µg/ml
  • epitope mapping near the C-terminus of JAK3 of human origin
  • recommended for detection of JAK3 of human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
  • blocking peptide, sc-1080 P
  • See 3 citations for JAK3 Antibody (H-20)
 

See additional JAK Antibodies including JAK, JAK1, JAK2 and JAK3.

Also see JAK3 Inhibitors for functional analysis of cellular responses to JAK3.


Ordering InformationProduct CitationsGene Info
Recommended Support Products:
(click button of application of choice)
WB   IF   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
JAK3 Antibody (H-20) sc-1080 200 µg/ml $279
JAK3 (H-20) P sc-1080 P
(peptide)
 100 µg/0.5 ml $61
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
JAK3 siRNA (h) sc-29379 10 µM $258
JAK3 (h)-PR sc-29379-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
JAK3 shRNA Plasmid (h) sc-29379-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
JAK3 shRNA (h) Lentiviral Particles sc-29379-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
HuT 78 Whole Cell Lysate sc-2208 500 µg/200 µl $104
MOLT-4 Cell Lysate sc-2233 500 µg/200 µl $104
HeLa Whole Cell Lysate sc-2200 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human JAK3 3718 19p13.11 NM_000215 P52333
 600173
 

JAK3 (Janus kinase 3) belongs to the family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK3. JAK3 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. The canonical JAK/Stat pathway is integral to maintaining a normal immune system, stimulating proliferation, differentiation, survival and host resistance to pathogens. Altering JAK/Stat signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies.

JAK3 Antibody (H-20) Product Citations
See how others have used JAK3 Antibody (H-20) and or JAK3 Antibody (H-20) conjugates.


3 total citations
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