BAF170 Background Information The SWI/SNF complex is involved in the activation of transcription via the remodeling of nucleosome structure in an ATP-dependent manner. Brm (also designated SNF2a) and Brg-1 (also designated SNF2b) are the ATPase subunits of the mammalian SWI/SNF complex. Brm, Brg-1, Ini1 (integrase interactor 1, also designated SNF5), BAF155 (also designated SRG3) and BAF170 are thought to comprise the functional core of the SWI/SNF complex. Addition of Ini1, BAF155 and BAF170 to Brg-1 appears to increase remodeling activity. Other complex subunits are thought to play regulatory roles. hSNF2L and hSNF2H both appear to be homologs of Drosophila Isw1, a BRM related ATPase that is present in chromatin remodeling complexes other than SWI/SNF, including the NURF (nucleosome remodeling factor).
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BAF170 (H-116)
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BAF170 (H-116): sc-10757. Western blot analysis of BAF170 expression in A-431 nuclear extract.
BAF170 (H-116): sc-10757. Western blot analysis of BAF170 expression in A-431 (A) and K-562 (B) whole cell lysates.
BAF170 (H-116): sc-10757. Western blot analysis of BAF170 expression in non-transfected 293T: sc-117752 (A) and human BAF170 transfected 293T: sc-113750 (B) whole cell lysates and K-562 nuclear extract (C).
BAF170 (H-116): sc-10757. Western blot analysis of BAF170 expression in non-transfected: sc-117752 (A) and human BAF170 transfected: sc-175518 (B) 293T whole cell lysates and HeLa nuclear extract (C).
BAF170 (H-116): sc-10757. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.
