epitope corresponding to amino acids 419-501 of BACE of mouse origin
recommended for detection of BACE of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
BACE Background Information Autosomal dominant Alzheimer’s disease is caused by mutations in the gene encoding the ß-amyloid protein precursor (APP). Amyloid ß-peptide (Aß), the major feature of amyloid plaques in Alzheimer’s patients, is the product of APP cleavage by ß- and g-secretases. BACE is the transmembrane protease which cleaves Aß from APP. BACE and the related protein Asp1 are both widely expressed in human tissue with the highest levels in the pancreas. BACE is localized within Golgi and endosomes.
BACE (M-83) Product Citations
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BACE (M-83)
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BACE (M-83): sc-10748. Western blot analysis of human recombinant BACE fusion protein.
BACE (M-83): sc-10748. Western blot analysis of BACE expression in non-transfected: sc-117752 (A) and human BACE transfected: sc-159912 (B) 293T whole cell lysates.
