epitope mapping at the N-terminus of TIP120A of rat origin
recommended for detection of TIP120A of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, bovine and porcine
blocking peptide, sc-10672 P
TransCruz reagent for Gel Supershift and ChIP applications, sc-10672 X, 200 µg/0.1 ml
TIP120A Background Information TATA-binding protein (TBP) forms complexes with various nuclear proteins and is a target for various transcriptional regulators, such as TIP120. The two members of the TIP120 family of proteins, TIP120A and TIP120B, are TBP-Interacting Proteins that function as global activators in transcriptional regulation. TIP120A is a ubiqitously expressed protein isolated from rat liver nuclear extracts, originally named TIP120. TIP120B is a TIP-120A-like protein that is expressed specifically in muscle tissues. TIP120A binds directly to TBP and a particular subunit of RNA polymerases (RNAP) to facilitate specific integration of RNAP II into the preinitiation complex (PIC). In addition to being a transcription factor of TBP, the chaperone-like activity toward the RNA polymerases demonstrates that TIP120 regulates the amplification of multiple gene expression.
TIP120A (A-13) Product Citations
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TIP120A (A-13)
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TIP120A (A-13): sc-10672. Western blot analysis of TIP120A expression in Jurkat (A) and HeLa (B) nuclear extracts and rat testis tissue extract (C).
TIP120A (A-13): sc-10672. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.
