epitope mapping near the C-terminus of WSTF of human origin
recommended for detection of human WSTF and WBSCR9 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
blocking peptide, sc-10637 P
TransCruz reagent for Gel Supershift and ChIP applications, sc-10637 X, 200 µg/0.1 ml
WSTF Background Information WSTF (Williams Syndrome transcription factor), also known as WBSCR9, is encoded by the BAZ1B gene, which, through deletion, is considered a contributory factor for the human developmental disorder Williams Syndrome. WSTF is ubiqitiously expressed in adult and fetal tissues and is involved in chromatin remodeling and modulation of transcription. A closely related gene, BAZ1A, encodes WCRF, also a chromatin remodeling protein important for development. WSTF incorporates several features that operate in chromatin remodeling and modulation of transcription, including a PHD finger, which is a zinc-finger-like motif rich in cysteine; a bromodomain, which is thought to mediate interactions with histones; and several nuclear binding motifs.
