epitope mapping within an internal region of BAZ1A of human origin
recommended for detection of BAZ1A of human origin and cbp146 of mouse origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
blocking peptide, sc-10629 P
TransCruz reagent for Gel Supershift and ChIP applications, sc-10629 X, 200 µg/0.1 ml
BAZ1A Background Information Chromatin remodeling complexes are suggested to provide a level of regulatory control and specificity of chromatin remodeling processes. Based upon their associated ATPase, chromatin remodeling complexes are organized into four different families, SWI/SNF, ISWI, CHD and INO80. Several members of the BAZ/WAL family interact independently with hSNF2H, the human homolog of Drosophilia ISWI, to form chromatin remodeling factors. BAZ1A (bromodomain adjacent to zinc finger domain, 1A), also known as ACF1, WALp1, hACF1 or WCRF180), is a 1,556 amino acid nuclear protein that is highly expressed in testis and consists of several conserved structures including a bromo domain, a DDT domain, a PHD-type zinc finger and a WAC motif. Belonging to the BAZ/WAL family, BAZ1A is closely related to Williams syndrome transcription factor (WSTF) and may participate in transcriptional regulation and in the formation of heterochromatin, thereby indicating a critical role in developmental control. Together with CHRAC15, CHRAC17 and hSNF2H proteins, BAZ1A forms an ISWI chromatin-remodeling complex.
