epitope mapping at the C-terminus of cyclin C of human origin
recommended for detection of cyclin C of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
cyclin C Background Information The proliferation of eukaryotic cells is controlled at specific points in the cell cycle, particularly at the G1 to S and the G2 to M transitions. It is well established that the Cdc2 p34-cyclin B protein kinase plays a critical role in the G2 to M transition while cyclin A associates with Cdk2 p33 and functions in S phase. Considerable effort directed towards the identi- fication of G1 cyclins has led to the isolation of cyclin D, cyclin C and cyclin E. Cyclin D corresponds to a putative human oncogene designated PRAD1 which maps at the site of the BCL1 rearrangement in certain lymphomas and leukemias. Cyclin C complexes with the cyclin dependent kinase Cdk8. The cyclin C/Cdk8 complex has been shown to have kinase activity toward the carboxy terminal domain of RNA polymerase II. Two complexes have been identified which contain cyclin C/Cdk8.
cyclin C (T-19) Product Citations
See how others have used cyclin C (T-19): sc-1061 antibody and or cyclin C (T-19) antibody conjugates.
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cyclin C (T-19)
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Western blot analysis of human recombinant cyclin C fusion protein. Antibodies tested include cyclin C (T-19): sc-1061 (A) and cyclin C (C-19): sc-5333 (B).
cyclin C (T-19): sc-1061. Immunoperoxidase staining of formalin fixed, paraffin-embedded human nasopharinx tissue showing nuclear and cytoplasmic staining of surface epithelial cells (low and high magni?fication). Kindly provided by The Swedish Human Protein Atlas (HPA) program.
cyclin C (T-19): sc-1061. Western blot analysis of cyclin C expression in non-transfected: sc-117752 (A) and human cyclin C transfected: sc-112866 (B) 293T whole cell lysates.
cyclin C (T-19): sc-1061. Western blot analysis of cyclin C expression in rat skeletal muscle tissue extract.
