epitope mapping near the N-terminus of CPS1 of human origin
recommended for detection of CPS1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine and porcine
CPS1 Background Information The multicomplex protein, carbamoyl-phosphate synthetase-aspartate carbamoyl transferase-dihydro-orotase (CAD), consists of three distinct proteins, carbamoyl phosphate synthetase 2 (CPS2), aspartate transcarbamylase, and dihydro-orotase, which catalyze the second and third steps of pyrimidine biosynthesis. CAD is allosterically regulated by the phosphorylation of CPS2 by cyclic AMP-dependent protein kinase, and this activation enables CPS2 to catalyze the rate-limiting step of pyrimidine synthesis. CAD is expressed in brain and skeletal muscle. A related protein, carbamoyl phosphate synthetase 1 (CPS1) is expressed in liver. CPS1 catalyzes the rate-limiting step in the urea cycle, and deficiency of CPS1 is an autosomal recessive disorder that causes hyperammonemia.
CPS1 (N-18)
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CPS1 (N-18): sc-10515. Western blot analysis of CPS1 expression in rat brain tissue extract.
