Podocalyxin-like 1 (K-19) Antibody: sc-10503

Podocalyxin-like 1 Background Information
Sialomucins are a family of cell adhesion molecules that mediate the interaction between leukocytes and endothelial cells during the inflammatory process. Podocalyxin-like protein 1 (PCLP1), a member of the sialomucin family, is a transmembrane glycoprotein and is structurally related to the L-Selectin ligand, CD34. Podocalyxin-like protein 1 encodes a 21 amino acid N-terminal signal peptide and a 26 amino acid transmembrane region. The extracellular domain contains sites for N- and O-linked glycosylation and the intracellular domain has several potential phosphorylated sites. Podocalyxin-like protein 1 is expressed on podocyte foot processes, where it maintains the glomerular filtration barrier. It is also expressed in endo-thelial cells as well as hemangioblasts, a precursor of hematopoietic stem cells (HSC). Subsequently, Podocalyxin-like protein 1 is thought to be an appropriate marker for hemagioblast detection.