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USP1 Antibody (E-14): sc-104735

 |  Datasheet

(Based on data analysis)

  • USP1 Antibody (E-14) is a goat polyclonal IgG provided at 200 µg/ml
  • epitope mapping within an internal region of USP1 of human origin
  • recommended for detection of USP1 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
  • blocking peptide, sc-104735 P
 

See additional USP Antibodies including USP, USP1, USP17, USP27, USP46, USP2, USP3, USP4, USP5, USP6, USP9, USP9X, USP9Y, USP10, USP11, USP12, USP13, USP14, USP15, USP18, USP19, USP20, USP21, USP22, USP24, USP25, USP26, USP28, USP29, USP30, USP31, USP32, USP33, USP34, USP35, USP36, USP37, USP38, USP39, USP40, USP42, USP43, USP44, USP45, USP47, USP48, USP49, USP50, USP51, USP52, USP53, USP54 and USP17L4.

Also see USP Inhibitors for functional analysis of cellular responses to USP.


Ordering InformationGene Info
Recommended Support Products:
(click button of application of choice)
WB   IF   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
USP1 Antibody (E-14) sc-104735 200 µg/ml $279
USP1 (E-14) P sc-104735 P
(peptide)
100 µg/0.5 ml $61
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
USP1 siRNA (h) sc-88494 10 µM $258
USP1 siRNA (m) sc-106677 10 µM $258
USP1 (h)-PR sc-88494-PR 10 µM, 20 µl $23
USP1 (m)-PR sc-106677-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
USP1 shRNA Plasmid (h) sc-88494-SH 20 µg $520
USP1 shRNA Plasmid (m) sc-106677-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
USP1 shRNA (h) Lentiviral Particles sc-88494-V 200 µl $625
USP1 shRNA (m) Lentiviral Particles sc-106677-V 200 µl $625
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human USP1 7398 1p31.3 O94782
603478
 


The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. Through the use of a wide range of enzymes that can add or remove ubiquitin, the Ub pathway controls many intracellular processes such as signal transduction, transcriptional activation and cell cycle progression. USP1 (ubiquitin specific peptidase 1), also known as UBP, ubiquitin carboxyl-terminal hydrolase 1, ubiquitin thioesterase 1 or deubiquitinating enzyme 1, is a 785 amino acid that belongs to the peptidase C19 family of ubiquitin carboxy-terminal hydrolases. A negative regulator of DNA damage repair, USP1 specifically deubiquitinates FANCD2 in the DNA repair pathway. Following DNA damage, autocatalytic cleavage of USP1 leads to an increase in ubiquitinated PCNA and the recruitment of POL H. Multiple isoforms of USP1 exist due to alternative splicing events.