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home » Transcription Regulators » HP1 Antibody / HP1 Antibodies » HP1γ (E-16): sc-10214

HP1γ (E-16) Antibody: sc-10214

  |  Datasheet
  • goat polyclonal IgG, 200 µg/ml
  • epitope mapping within an internal region of HP1γ of human origin
  • recommended for detection of HP1γ of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
  • blocking peptide, sc-10214 P
 
Additional HP1 Antibodies ...
 
Ordering Information
Recommended Support Products:
(click button of application of choice)
WB   IF   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human CBX3 11335 7p15.2 NM_007276, NM_016587 Q13185
 604477
Mouse Cbx3 12417 6 B3 P23198
 N/A
 
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
HP1γ (E-16) sc-10214 200 µg/ml $279
HP1γ (E-16) P sc-10214 P
(peptide)
 100 µg/0.5 ml $61
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
HP1γ siRNA (h) sc-35589 10 µM $258
HP1γ siRNA (m) sc-35590 10 µM $258
HP1γ (h)-PR sc-35589-PR 10 µM $23
HP1γ (m)-PR sc-35590-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
HP1γ shRNA Plasmid (h) sc-35589-SH 20 µg $520
HP1γ shRNA Plasmid (m) sc-35590-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
HP1γ shRNA (h) Lentiviral Particles sc-35589-V 200 µl $625
HP1γ shRNA (m) Lentiviral Particles sc-35590-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
HeLa nuclear extract sc-2120 1000 µg $143
K-562 nuclear extract sc-2130 1000 µg $143
NIH/3T3 nuclear extract sc-2138 1000 µg $143
HeLa Whole Cell Lysate sc-2200 500 µg/200 µl $104

HP1γ Background Information
Chromatin assembly factor-1 (CAF-1) is a multisubunit protein complex that comprises three polypeptide subunits known as p150, p60, and p48. CAF-1 is a nucleosome assembly factor that deposits newly synthesized and acetylated histones H3/H4 into nascent chromatin during DNA replication. The p150 subunit of CAF-1 also supports the maintenance of heterochromatin, which requires the synthesis of both new histones and heterochromatin proteins and their orderly assembly during DNA replication. Heterochromatin is characterized as densely coiled chromatin that generally replicates late during S phase, has a low gene density, and contains large blocks of repetitive DNA that is relatively inaccessible to DNA-modifying reagents. In late S phase, p150 directly associates with heterochromatin associated proteins 1 (HP1å, HP1∫ and HP1©). As cells prepare for mitosis, CAF-1 p150 and some HP1 progressively dissociate from heterochromatin, coinciding with the phosphorylation of Histone H3. The HP1 proteins reassociate with chromatin at the end of mitosis, as Histone H3 is dephosphorylated.