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PRPF3 Antibody (O-23): sc-102068

 |  Datasheet

(Based on data analysis)

  • PRPF3 Antibody (O-23) is a rabbit polyclonal IgG provided at 50 µg/0.5 ml
  • raised against PRPF3 of human origin
  • recommended for detection of PRPF3 of mouse, rat, human and canine origin by WB, IP and ELISA
 

See additional PRPF Antibodies including PRPF, PRPF38B, PRPF39, PRPF40B, PRPF3, PRPF4, PRPF18, PRPF31 and PRPF38A.

Ordering InformationGene Info
Recommended Support Products:
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WB   IP   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
PRPF3 Antibody (O-23) sc-102068 50 µg/0.5 ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
PRPF3 siRNA (h) sc-88819 10 µM $258
PRPF3 siRNA (m) sc-152493 10 µM $258
PRPF3 (h)-PR sc-88819-PR 10 µM, 20 µl $23
PRPF3 (m)-PR sc-152493-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
PRPF3 shRNA Plasmid (h) sc-88819-SH 20 µg $520
PRPF3 shRNA Plasmid (m) sc-152493-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
PRPF3 shRNA (h) Lentiviral Particles sc-88819-V 200 µl $625
PRPF3 shRNA (m) Lentiviral Particles sc-152493-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Hep G2 Cell Lysate sc-2227 500 µg/200 µl $104
HeLa nuclear extract sc-2120 250 µg/0.05 ml $143
JAR Cell Lysate sc-2276 500 µg/200 µl $104
PRPF31 (m): 293T Lysate sc-127395 100 µg/200 µl $205
PRPF31 (m2): 293T Lysate sc-127396 100 µg/200 µl $205
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human PRPF3 9129 1q21.2 NM_004698 O43395
607301
Mouse Prpf3 70767 3 F2.1 Q922U1
N/A
 


PRPF3 (PRP3 pre-mRNA processing factor 3 homolog), also known as RP18, PRP3, Prp3p, HPRP3 or HPRP3P, is an evolutionarily conserved protein involved in pre-mRNA splicing and functions as a component of the U4/U6.U5 tri-snRNP (small nuclear ribonucleoprotein) complex. Ubiquitously expressed with predominant expression in retina, blood, kidney and liver, PRPF3 localizes to nuclear speckles and is phosphorylated in vitro. PRPF3 directly interacts with PRPF4 and is present in the inactive spliceosome but is not found in the catalytically active spliceosome. Mutations in the gene encoding PRPF3 result in autosomal dominant retinitis pigmentosa type 18 (RP18), which leads to photoreceptor cell degeneration. RP18 patients initially exhibit a loss of their midperipheral visual field as well as night vision blindness. The disease eventually progresses to the loss of far peripheral visual field and finally the loss of central vision. This suggests that PRPF3 is a key player in the pre-mRNA splicing of photoreceptor-specific genes.

PRPF3 Antibody (O-23) Data
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PRPF3 (O-23): sc-102068. Western blot analysis of PRPF3 expression in Hep G2 whole cell lysate.
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