p-Stat4 Antibody (Tyr 693): sc-101804

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Membrane receptor signaling by various ligands, including interferons and growth hormones, induces activation of Jak kinases, which then leads to tyrosine phosphorylation of the Stat transcription factors. Upon activation by tyrosine phosphorylation, Stat proteins dimerize, translocate to the nucleus and bind to specific regulatory elements that control gene expression. Stat4 is most highly expressed in testis and myeloid cells and is an important element in mediating IL-12 signals. IL-12 induces sustained activation and nuclear translocation of Stat4, a process coupled to both tyrosine and serine phosphorylation of Stat4. Phosphorylation of Ser 721 of Stat4 is MEK-, ERK- and JNK-independent and p38-dependent, and is necessary for the transcriptional activity of Stat4.