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p-MEK-4 Antibody (Thr 261): sc-101795

 |  Datasheet

(Based on data analysis)

  • p-MEK-4 Antibody (Thr 261) is a rabbit polyclonal IgG provided at 100 µg/ml
  • epitope corresponding to phosphorylated Thr 261 of MEK-4 of human origin
  • recommended for detection of Thr 261 phosphorylated MEK-4 of human origin and correspondingly phosphorylated Thr 259 of mouse and rat origin by IF and IHC(P)
 

See additional MEK Antibodies including MEK, MEK, MEK-1, MEK-2, MEK-3, MEK-4, MEK-5, MEK-6 and MEK-7.

Also see MEK-5 Inhibitors for functional analysis of cellular responses to MEK-4.


Ordering InformationGene Info
Recommended Support Products:
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IF   IHC(P)   siRNA  
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
p-MEK-4 Antibody (Thr 261) sc-101795 100 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
MEK-4 siRNA (h) sc-35909 10 µM $258
MEK-4 siRNA (m) sc-35910 10 µM $258
MEK-4 (h)-PR sc-35909-PR 10 µM, 20 µl $23
MEK-4 (m)-PR sc-35910-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
MEK-4 shRNA Plasmid (h) sc-35909-SH 20 µg $520
MEK-4 shRNA Plasmid (m) sc-35910-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
MEK-4 shRNA (h) Lentiviral Particles sc-35909-V 200 µl $625
MEK-4 shRNA (m) Lentiviral Particles sc-35910-V 200 µl $625
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human MAP2K4 6416 17p12 NM_003010 P45985
 601335
Mouse Map2k4 26398 11 B3 P47809
 N/A
 

A family of protein kinases located upstream of the MAP kinases and responsible for their activation has been identified. The prototype member of this family, designated MAP kinase kinase, or MEK-1, specifically phosphorylates the MAP kinase regulatory threonine and tyrosine residues present in the Thr-Glu-Tyr motif of ERK (1). A second MEK family member, MEK-2, resembles MEK-1 in its substrate specificity (2). MEK-3 (or MKK-3) functions to activate p38 MAP kinase, and MEK-4 (also called SEK1 or MKK-4) activates both p38 and JNK MAP kinases (3). MEK-5 appears to specifically phosphorylate ERK5 (4), whereas MEK-6 phosphorylates p38 and p38b (5,6). MEK-7 (or MKK-7) phosphorylates and activates the JNK signal transduction pathway (7–9).

p-MEK-4 Antibody (Thr 261) Data
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sc-101795
p-MEK-4 (Thr 261): sc-101795. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast carcinoma tissue showing cytoplasmic and membrane staining.
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