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p-PLC γ2 Antibody (Tyr 753): sc-101785

 |  Datasheet

(Based on data analysis)

  • p-PLC γ2 Antibody (Tyr 753) is a rabbit polyclonal IgG provided at 100 µg/ml
  • epitope corresponding to phosphorylated Tyr 753 of PLC γ2 of human origin
  • recommended for detection of Tyr 753 phosphorylated PLC γ2 of mouse, rat and human origin by WB and IP
 

See additional PLC Antibodies including PLC, PLC beta 1, PLC delta 1, PLC epsilon, PLC eta 1, PLC gamma 1, PLC zeta, PLC-L, PLC-XD1, PLC beta 2, PLC epsilon 2, PLC eta 2, PLC gamma 2, PLC beta 3, PLC delta 3, PLC beta 4 and PLC delta 4.

Also see PLC Inhibitors, PLC Activators or PLC Substrates for functional analysis of cellular responses to PLC.


Ordering InformationGene Info
Recommended Support Products:
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WB   IP   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
p-PLC γ2 Antibody (Tyr 753) sc-101785 100 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
PLC γ2 siRNA (h) sc-36268 10 µM $258
PLC γ2 siRNA (m) sc-36269 10 µM $258
PLC γ2 (h)-PR sc-36268-PR 10 µM, 20 µl $23
PLC γ2 (m)-PR sc-36269-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
PLC γ2 shRNA Plasmid (h) sc-36268-SH 20 µg $520
PLC γ2 shRNA Plasmid (m) sc-36269-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
PLC γ2 shRNA (h) Lentiviral Particles sc-36268-V 200 µl $625
PLC γ2 shRNA (m) Lentiviral Particles sc-36269-V 200 µl $625
 WB Positive Control Cell Lysate (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
A-431 + EGF Whole Cell Lysate sc-2202 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human PLCG2 5336 16q23.2 NM_002661 P16885
 600220
Mouse Plcg2 234779 8 E1 Q8CIH5
 N/A
 

Phosphoinositide-specific phospholipase C (PLC) plays a critical role in the initiation of receptor mediated signal transduction through the generation of the two second messengers, inositol 1,4,5-triphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate.There are many mammalian PLC isozymes, including PLC ∫1, PLC ∫2, PLC ∫3, PLC ∫4, PLC ©1, PLC ©2, PLC ∂1, PLC ∂2 and PLC e. After stimulation of the collagen receptor glycoprotein VI in human platelets, PLC ©2 associates with several tyrosine-phosphorylated proteins (Syk, SLP-76, Lyn, linker for activation of T cells (LAT) and the FcR © chain), which bind to its C-terminal SH2 domain. PLC ©1 associates with Syk in B cells, but PLC ©2 does not associate with Syk in platelets. The C-terminal SH2 domain is involved in the regulation of PLC ©2. In addition, Btk can induce PLC ©2 tyrosine phosphorylation and initiate calcium moblization in CD72-stimulated B lymphocytes.
p-PLC γ2 Antibody (Tyr 753) Data
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sc-101785
p-PLC γ2 (Tyr 753): sc-101785. Western blot analysis of phosphorylated PLC γ2 expression in untreated (A) and EGF-treated (B) A-431 whole cell lysates.
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