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p-p73 Antibody (Tyr 99): sc-101769

 |  Datasheet

(Based on data analysis)

  • p-p73 Antibody (Tyr 99) is a rabbit polyclonal IgG provided at 100 µg/ml
  • epitope corresponding to phosphorylated Tyr 99 of p73 of human origin
  • recommended for detection of Tyr 99 phosphorylated p73 of human origin; correspondingly phosphorylated Tyr 91 of mouse origin and correspondingly phosphorylated Tyr 144 of rat origin by WB and IP
 

See additional p73 Antibodies including p73, deltaN p73 and p73 alpha.

Also see chemical p73 Activators for functional analysis of cellular responses to p73.


Ordering InformationGene Info
Recommended Support Products:
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WB   IP   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
p-p73 Antibody (Tyr 99) sc-101769 100 µg/ml $279
 CRISPR/Cas9 KO and HDR Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
p73 CRISPR/Cas9 KO Plasmid (h) sc-416822 20 µg $345
p73 HDR Plasmid (h) sc-416822-HDR 20 µg $385
p73 CRISPR/Cas9 KO Plasmid (m) sc-423511 20 µg $345
p73 HDR Plasmid (m) sc-423511-HDR 20 µg $385
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
p73 siRNA (h) sc-36167 10 µM $258
p73 siRNA (m) sc-36168 10 µM $258
p73 siRNA (h2) sc-43730 10 µM $258
p73 (h)-PR sc-36167-PR 10 µM, 20 µl $23
p73 (m)-PR sc-36168-PR 10 µM, 20 µl $23
p73 (h2)-PR sc-43730-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
p73 shRNA Plasmid (h) sc-36167-SH 20 µg $520
p73 shRNA Plasmid (m) sc-36168-SH 20 µg $520
p73 shRNA Plasmid (h2) sc-43730-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
p73 shRNA (h) Lentiviral Particles sc-36167-V 200 µl $625
p73 shRNA (m) Lentiviral Particles sc-36168-V 200 µl $625
p73 shRNA (h2) Lentiviral Particles sc-43730-V 200 µl $625
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human TP73 7161 1p36.32 NM_005427 O15350
601990
Mouse Trp73 22062 4 E2 NP_035772
N/A
 


The p53 gene is a widely studied anti-oncogene, or tumor suppressor gene. The p53 gene product can act as a negative regulator of cell growth in response to DNA damage. Mutations and allelic loss of the p53 gene have been associated with malignant transformation in a wide variety of human tumors. p53 shares considerable sequence similarity with p73, a gene that maps to a region in chromosome 1 that is frequently deleted in neuroblastomas. However, p73 does not appear to be activated by DNA damaging agents. The p73 isoform p73å inhibits drug-induced apoptosis in small cell lung carcinoma cells, while the p73 isoform p73∫ promotes it. p73å also prevents Bax activation, mitochondrial dysfunction, caspase activation and is able to reduce apoptosis induced by the BH3-only protein PUMA (p53 upregulated modulator of apoptosis). There is an equilibrium between p73å and p73∫, demonstrated by the fact that p73å inhibits the pro-apoptotic effect of p73∫.