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p-Dok-1 Antibody (Tyr 398): sc-101767

 |  Datasheet

(Based on data analysis)

  • p-Dok-1 Antibody (Tyr 398) is a rabbit polyclonal IgG provided at 100 µg/ml
  • epitope corresponding to phosphorylated Tyr 398 of Dok-1 of human origin
  • recommended for detection of Tyr 398 phosphorylated Dok-1 of mouse, rat and human origin by WB, IP, IF and IHC(P)
 

See additional Dok Antibodies including Dok, Dok-1, Dok-2, Dok-3, Dok-4, Dok-5, Dok-6 and Dok-7.

Ordering InformationGene Info
Recommended Support Products:
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WB   IP   IF   IHC(P)   siRNA  
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
p-Dok-1 Antibody (Tyr 398) sc-101767 100 µg/ml $279
Lambda Phosphatase sc-200312 100000 units in 0.25 ml $462
Lambda Phosphatase sc-200312A 20000 units in 0.05 ml $116
Lambda Phosphatase sc-200312 100000 units in 0.25 ml $462
Lambda Phosphatase sc-200312A 20000 units in 0.05 ml $116
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Dok-1 siRNA (h) sc-35210 10 µM $258
Dok-1 siRNA (m) sc-35209 10 µM $258
Dok-1 (h)-PR sc-35210-PR 10 µM, 20 µl $23
Dok-1 (m)-PR sc-35209-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Dok-1 shRNA Plasmid (h) sc-35210-SH 20 µg $520
Dok-1 shRNA Plasmid (m) sc-35209-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Dok-1 shRNA (h) Lentiviral Particles sc-35210-V 200 µl $625
Dok-1 shRNA (m) Lentiviral Particles sc-35209-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Jurkat Whole Cell Lysate sc-2204 500 µg/200 µl $104
Dok-1 (m): 293T Lysate sc-119822 100 µg/200 µl $205
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human DOK1 1796 2p13.1 NM_001381 Q99704
 602919
Mouse Dok1 13448 6 C3 P97465
 N/A
 

Dok-1 associates with the Ras GTPase activating protein (Ras GAP) upon tyrosine phosphorylation. Evidence suggests that p62 Dok-1 is a substrate of the constitutive tyrosine kinase activity of p210 Bcr-Abl, a fusion protein caused by the t(9;22) translocation and associated with chronic myelogenous leukemia. Dok-1, as well as the tyrosine kinase substrates IRS-1 and Cas, is a member of a class of “docking” proteins which contain multiple tyrosine residues and putative SH2 binding sites. Dok-1 is suspected to be the substrate phosphorylated in response to stimulation by a number of growth factors, including PDGF, VEGF, insulin and IGF. Dok-2 (also designated p56 Dok) has also been identified as a potential mediator of the effects of p210 Bcr-Abl.
p-Dok-1 Antibody (Tyr 398) Data
Click on image to enlarge
sc-101767
p-Dok-1 (Tyr 398): sc-101767. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast carcinoma tissue showing nuclear and cytoplasmic staining.
sc-101767
p-Dok-1 (Tyr 398): sc-101767. Western blot analysis of phosphorylated Dok-1 expression in K-562 (A) and serum starved K-562 (B) whole cell lysates.
sc-101767
p-Dok-1 (Tyr 398): sc-101767. Western blot analysis of Dok-1 phosphorylation in non-transfected: sc-117752 (A), untreated mouse Dok-1 transfected: sc-119822 (B) and lambda protein phosphatase treated mouse Dok-1 transfected: sc-119822 (C) 293T whole cell lysates.
sc-101767
p-Dok-1 (Tyr 398): sc-101767. Western blot analysis of Dok-1 phosphorylation in non-transfected: sc-117752 (A), untreated mouse Dok-1 transfected: sc-119822 (B) and lambda protein phosphatase treated mouse Dok-1 transfected: sc-119822 (C) 293T whole cell lysates.
sc-101767
Western blot analysis of Dok-1 phosphorylation in non-transfected: sc-117752 (A, D), untreated mouse Dok-1 transfected: sc-119822 (B, E) and lambda protein phosphatase treated mouse Dok-1 transfected: sc-119822 (C, F) 293T whole cell lysates. Antibodies tested include p-Dok-1 (Tyr 398): sc-101767 (A, B, C) and Dok-1 (M-276): sc-6934 (D, E, F).
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