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p-IκB-α Antibody (Ser 32/36): sc-101713

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  • p-IκB-α Antibody (Ser 32/36) is a rabbit polyclonal IgG provided at 100 µg/ml
  • epitope corresponding to phosphorylated Ser 32/36 of IκB-α of human origin
  • recommended for detection of Ser 32 and Ser 36 dually phosphorylated IκB-α of mouse, rat and human origin by WB, IP, IF and IHC(P)
  • See 26 citations for p-IκB-α Antibody (Ser 32/36)

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p-IκB-α (Ser 32/36) will be discontinued December 31, 2016; to receive a 10 µg sample of p-IκB-α (B-9): sc-8404, our highly recommended and much superior monoclonal antibody alternative to this product, please contact Technical Service.

 

See additional I κ B Antibodies including I κ B, I κ B-ε, I κ B-ζ, I kappa B-α, I kappa B-β and I kappa B-δ.

Also see chemical I kappa B-alpha Inhibitors for functional analysis of cellular responses to I kappa B-α.


Ordering InformationProduct CitationsGene Info
Recommended Support Products:
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WB   IP   IF   IHC(P)   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
p-IκB-α Antibody (Ser 32/36) sc-101713 100 µg/ml $279
Lambda Phosphatase sc-200312 100000 units in 0.25 ml $462
Lambda Phosphatase sc-200312A 20000 units in 0.05 ml $116
 CRISPR KO, HDR and Nickase Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
IκB-α CRISPR/Cas9 KO Plasmid (m) sc-421878 20 µg $345
IκB-α HDR Plasmid (m) sc-421878-HDR 20 µg $385
IκB-α Double Nickase Plasmid (m) sc-421878-NIC 20 µg $355
IκB-α Double Nickase Plasmid (m2) sc-421878-NIC-2 20 µg $355
IκB-α CRISPR/Cas9 KO Plasmid (h) sc-400034 20 µg $345
IκB-α HDR Plasmid (h) sc-400034-HDR 20 µg $385
IκB-α Double Nickase Plasmid (h) sc-400034-NIC 20 µg $355
IκB-α Double Nickase Plasmid (h2) sc-400034-NIC-2 20 µg $355
 CRISPR Activation Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
IκB-α CRISPR Activation Plasmid (m) sc-421878-ACT 20 µg $345
IκB-α CRISPR Activation Plasmid (m2) sc-421878-ACT-2 20 µg $345
IκB-α Lentiviral Activation Particles (m) sc-421878-LAC 200 µl $395
IκB-α Lentiviral Activation Particles (m2) sc-421878-LAC-2 200 µl $395
IκB-α CRISPR Activation Plasmid (h) sc-400034-ACT 20 µg $345
IκB-α CRISPR Activation Plasmid (h2) sc-400034-ACT-2 20 µg $345
IκB-α Lentiviral Activation Particles (h) sc-400034-LAC 200 µl $395
IκB-α Lentiviral Activation Particles (h2) sc-400034-LAC-2 200 µl $395
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
IκB-α siRNA (h) sc-29360 10 µM $258
IκB-α siRNA (m) sc-29361 10 µM $258
IκB-α siRNA (h2) sc-44265 10 µM $258
IκB-α (h)-PR sc-29360-PR 10 µM, 20 µl $23
IκB-α (m)-PR sc-29361-PR 10 µM, 20 µl $23
IκB-α (h2)-PR sc-44265-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
IκB-α shRNA Plasmid (h) sc-29360-SH 20 µg $520
IκB-α shRNA Plasmid (m) sc-29361-SH 20 µg $520
IκB-α shRNA Plasmid (h2) sc-44265-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
IκB-α shRNA (h) Lentiviral Particles sc-29360-V 200 µl $625
IκB-α shRNA (m) Lentiviral Particles sc-29361-V 200 µl $625
IκB-α shRNA (h2) Lentiviral Particles sc-44265-V 200 µl $625
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human NFKBIA 4792 14q13.2 NM_020529 P25963
164008
Mouse Nfkbia 18035 12 C1 Q9Z1E3
N/A
 


On the basis of both functional and structural considerations, members of the IκB family of proteins can be divided into four groups. The first of these groups, IκB-α, includes the avian protein pp40 and the mammalian MAD-3, both of which inhibit binding of p50–p65 NFkB complex or Rel protein to their cognate binding sites but do not inhibit the binding of p50 homodimer to κB sites, suggesting that the IκB-α family binds to the p65 subunit of p50–p65 heterocomplex through ankyrin repeats. The second member of the IκB family is represented by a protein designated IκB-β. The third group of IκB proteins is represented by IκB-γ, a protein identical in sequence with the C-terminal domain of the p110 precursor of NFkB p50 and expressed predominantly in lymphoid cells. An additional IκB family member has been identified as IκB-e, a protein which has several phosphorylated forms and is primarily found complexed with Rel A and/or c-Rel. There is a consensus phosphorylation site for CKII between residues 269-299, and within this range there are three phosphorylation sites that important for constitutive phosphorylation and intrinsic stability of IκB-α: Ser 283, Thr 291 and Thr 299.

p-IκB-α Antibody (Ser 32/36) Product Reviews

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p-IκB-α Antibody (Ser 32/36) Product Citations
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p-IκB-α Antibody (Ser 32/36) Data
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p-IκB-α (Ser 32/36): sc-101713. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast carcinoma tissue showing cytoplasmic staining.
p-IκB-α (Ser 32/36): sc-101713. Western blot analysis of IκB-α phosphorylation in untreated (A), TNFα treated (B) and TNFα and lambda protein phosphatase (sc-200312A) treated (C) HEK293 whole cell lysates.
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