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p-IκB-α Antibody (Ser 32/36): sc-101713

 |  Datasheet

(Based on data analysis)

  • p-IκB-α Antibody (Ser 32/36) is a rabbit polyclonal IgG provided at 100 µg/ml
  • epitope corresponding to phosphorylated Ser 32/36 of IκB-α of human origin
  • recommended for detection of Ser 32 and Ser 36 dually phosphorylated IκB-α of mouse, rat and human origin by WB, IP, IF and IHC(P)
  • See 16 citations for p-IκB-α Antibody (Ser 32/36)
 

See additional I kappa B Antibodies including I kappa B, I kappa B-alpha, I kappa B-beta, I kappa B-delta, I kappa B-epsilon and I kappa B-zeta.

Also see chemical I kappa B-alpha Inhibitors for functional analysis of cellular responses to I kappa B-alpha.


Ordering InformationProduct CitationsGene Info
Recommended Support Products:
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WB   IP   IF   IHC(P)   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
p-IκB-α Antibody (Ser 32/36) sc-101713 100 µg/ml $279
Lambda Phosphatase sc-200312 100000 units in 0.25 ml $462
Lambda Phosphatase sc-200312A 20000 units in 0.05 ml $116
 CRISPR/Cas9 KO and HDR Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
IκB-α CRISPR/Cas9 KO Plasmid (m) sc-421878 20 µg $345
IκB-α HDR Plasmid (m) sc-421878-HDR 20 µg $385
IκB-α CRISPR/Cas9 KO Plasmid (h) sc-400034 20 µg $345
IκB-α HDR Plasmid (h) sc-400034-HDR 20 µg $385
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
IκB-α siRNA (h) sc-29360 10 µM $258
IκB-α siRNA (m) sc-29361 10 µM $258
IκB-α siRNA (h2) sc-44265 10 µM $258
IκB-α (h)-PR sc-29360-PR 10 µM, 20 µl $23
IκB-α (m)-PR sc-29361-PR 10 µM, 20 µl $23
IκB-α (h2)-PR sc-44265-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
IκB-α shRNA Plasmid (h) sc-29360-SH 20 µg $520
IκB-α shRNA Plasmid (m) sc-29361-SH 20 µg $520
IκB-α shRNA Plasmid (h2) sc-44265-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
IκB-α shRNA (h) Lentiviral Particles sc-29360-V 200 µl $625
IκB-α shRNA (m) Lentiviral Particles sc-29361-V 200 µl $625
IκB-α shRNA (h2) Lentiviral Particles sc-44265-V 200 µl $625
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human NFKBIA 4792 14q13.2 NM_020529 P25963
164008
Mouse Nfkbia 18035 12 C1 Q9Z1E3
N/A
 


On the basis of both functional and structural considerations, members of the I˚B family of proteins can be divided into four groups. The first of these groups, I˚B-å, includes the avian protein pp40 and the mammalian MAD-3, both of which inhibit binding of p50–p65 NFkB complex or Rel protein to their cognate binding sites but do not inhibit the binding of p50 homodimer to ˚B sites, suggesting that the I˚B-å family binds to the p65 subunit of p50–p65 heterocomplex through ankyrin repeats. The second member of the I˚B family is represented by a protein designated I˚B-∫. The third group of I˚B proteins is represented by I˚B-©, a protein identical in sequence with the C-terminal domain of the p110 precursor of NFkB p50 and expressed predominantly in lymphoid cells. An additional I˚B family member has been identified as I˚B-e, a protein which has several phosphorylated forms and is primarily found complexed with Rel A and/or c-Rel. There is a consensus phosphorylation site for CKII between residues 269-299, and within this range there are three phosphorylation sites that important for constitutive phosphorylation and intrinsic stability of I˚B-å: Ser 283, Thr 291 and Thr 299.

p-IκB-α Antibody (Ser 32/36) Product Citations
See how others have used p-IκB-α Antibody (Ser 32/36) and or p-IκB-α Antibody (Ser 32/36) conjugates.


16 total citations
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p-IκB-α Antibody (Ser 32/36) Data
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p-IκB-α (Ser 32/36): sc-101713. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast carcinoma tissue showing cytoplasmic staining.
p-IκB-α (Ser 32/36): sc-101713. Western blot analysis of IκB-α phosphorylation in untreated (A), TNFα treated (B) and TNFα and lambda protein phosphatase treated (C) HEK293 whole cell lysates.
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