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p-IκB-ε Antibody (Ser 22): sc-101705

 |  Datasheet

(Based on data analysis)

  • p-IκB-ε Antibody (Ser 22) is a rabbit polyclonal IgG provided at 100 µg/ml
  • epitope corresponding to phosphorylated Ser 22 of IκB-ε of human origin
  • recommended for detection of Ser 22 phosphorylated IκB-ε of mouse and human origin by WB, IP, IF and IHC(P)
 

See additional I kappa B Antibodies including I kappa B, I kappa B-alpha, I kappa B-beta, I kappa B-delta, I kappa B-epsilon and I kappa B-zeta.

Also see I kappa B Inhibitors for functional analysis of cellular responses to I kappa B.


Ordering InformationGene Info
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   IHC(P)   siRNA  
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
p-IκB-ε Antibody (Ser 22) sc-101705 100 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
IκB-ε siRNA (h) sc-35642 10 µM $258
IκB-ε siRNA (m) sc-35643 10 µM $258
IκB-ε (h)-PR sc-35642-PR 10 µM, 20 µl $23
IκB-ε (m)-PR sc-35643-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
IκB-ε shRNA Plasmid (h) sc-35642-SH 20 µg $520
IκB-ε shRNA Plasmid (m) sc-35643-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
IκB-ε shRNA (h) Lentiviral Particles sc-35642-V 200 µl $625
IκB-ε shRNA (m) Lentiviral Particles sc-35643-V 200 µl $625
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human NFKBIE 4794 6p21.1 NM_004556 O00221
 604548
Mouse Nfkbie 18037 17 B3 O54910
 N/A
 

I˚B-ε (I-kappa-B-epsilon), also known as NFKBIE (NFκB inhibitor epsilon) or IKBE, is a 500 amino acid protein that belongs to the NFκB inhibitor family. Localizing to the cytoplasm, I˚B-ε is highly expressed in spleen, testis and lung, with lower levels of expression found in kidney, pancreas, heart, placenta, brain, granulocytes and macrophages. I˚B-ε inhibits c-Rel and NFκB subunits p50, p52 and p65 by forming a complex with them in the cytoplasm, preventing them from activating genes in the nucleus. I˚B-ε undergoes serine phosphorylation, resulting in the protein being marked for destruction via the ubiquitination pathway. Containing six ANK repeats, the gene encoding I˚B-ε maps to human chromosome 6p21.1.

p-IκB-ε Antibody (Ser 22) Data
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sc-101705
p-IκB-ε (Ser 22): sc-101705. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast carcinoma tissue showing cytoplasmic localization.
sc-101705
p-IκB-ε (Ser 22): sc-101705. Western blot analysis of phosphorylated IκB-ε expression in untreated (A) and TNF-α-treated (B) 293 whole cell lysates.
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