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p-EGFR Antibody (Tyr 1173): sc-101668

 |  Datasheet

(Based on data analysis)

  • p-EGFR Antibody (Tyr 1173) is a rabbit polyclonal IgG provided at 100 µg/ml
  • epitope corresponding to phosphorylated Tyr 1173 of EGFR of human origin
  • recommended for detection of Tyr 1173 phosphorylated EGFR of human and mouse origin and correspondingly phosphorylated Tyr 1172 of rat origin by WB, IP, IF and IHC(P)
  • See 15 citations for p-EGFR Antibody (Tyr 1173)
 

See additional EGFR Antibodies.

Also see EGFR Inhibitors or EGFR Substrates for functional analysis of cellular responses to EGFR.


Ordering InformationProduct CitationsGene Info
Recommended Support Products:
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WB   IP   IF   IHC(P)   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
p-EGFR Antibody (Tyr 1173) sc-101668 100 µg/ml $279
Lambda Phosphatase sc-200312 100000 units in 0.25 ml $462
Lambda Phosphatase sc-200312A 20000 units in 0.05 ml $116
Lambda Phosphatase sc-200312 100000 units in 0.25 ml $462
Lambda Phosphatase sc-200312A 20000 units in 0.05 ml $116
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
EGFR siRNA (h) sc-29301 10 µM $258
EGFR siRNA (m) sc-29302 10 µM $258
EGFR siRNA (h2) sc-44340 10 µM $258
EGFR siRNA (r) sc-108050 10 µM $258
EGFR (h)-PR sc-29301-PR 10 µM, 20 µl $23
EGFR (m)-PR sc-29302-PR 10 µM, 20 µl $23
EGFR (h2)-PR sc-44340-PR 10 µM, 20 µl $23
EGFR (r)-PR sc-108050-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
EGFR shRNA Plasmid (h) sc-29301-SH 20 µg $520
EGFR shRNA Plasmid (m) sc-29302-SH 20 µg $520
EGFR shRNA Plasmid (h2) sc-44340-SH 20 µg $520
EGFR shRNA Plasmid (r) sc-108050-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
EGFR shRNA (h) Lentiviral Particles sc-29301-V 200 µl $625
EGFR shRNA (m) Lentiviral Particles sc-29302-V 200 µl $625
EGFR shRNA (h2) Lentiviral Particles sc-44340-V 200 µl $625
EGFR shRNA (r) Lentiviral Particles sc-108050-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
A-431 + EGF Whole Cell Lysate sc-2202 500 µg/200 µl $104
SK-N-SH Cell Lysate sc-2410 500 µg/200 µl $104
A-431 Whole Cell Lysate sc-2201 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human EGFR 1956 7p11.2 NM_005228, NM_201282, NM_201283, NM_201284 P00533
 211980
Mouse Egfr 13649 11 A2 Q01279
 N/A
 

Epidermal growth factor mediates its effects on cell growth through its inter-action with a cell surface glycoprotein designated the EGF receptor. Binding of EGF or TGF alpha to the EGF receptor activates tyrosine-specific protein kinase activity intrinsic to the EGF receptor. The carboxy terminal tyrosine residues on EGFR, Tyr 1068 and Tyr 1173, are the major sites of autophosphorylation, which occurs as a result of EGF binding. Once activated, EGFR mediates the binding of the phosphotyrosine binding (PTB) domain of GRB2 through direct interactions with Tyr 1068 and Tyr 1086 and through indirect interactions with Tyr 1173 in the Ras signaling pathway. Tyr 1173 of EGFR also functions as a kinase substrate. Phosphorylation of Tyr 992, Tyr 1068 and Tyr 1086 is required for conformational change in the C-terminal tail of the EGF receptor.

p-EGFR Antibody (Tyr 1173) Product Citations
See how others have used p-EGFR Antibody (Tyr 1173) and or p-EGFR Antibody (Tyr 1173) conjugates.


15 total citations
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p-EGFR Antibody (Tyr 1173) Data
Click on image to enlarge
sc-101668
p-EGFR (Tyr 1173): sc-101668. Western blot analysis of phosphorylated EGFR expression in untreated (A) and EGF-treated (B) A-431 whole cell lysates.
sc-101668
p-EGFR (Tyr 1173): sc-101668. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast carcinoma tissue showing membrane staining.
sc-101668
p-EGFR (Tyr 1173): sc-101668. Western blot analysis of EGFR phosphorylation in untreated (A) and lambda protein phosphatase treated (B) A-431 whole cell lysates.
sc-101668
p-EGFR (Tyr 1173): sc-101668. Western blot analysis of EGFR phosphorylation in untreated (A), EGF treated (B) and EGF and lambda protein phosphatase treated (C) A-431 whole cell lysates.
sc-101668
Western blot analysis of EGFR phosphorylation in untreated (A, D), EGF treated (B, E) and EGF and lambda protein phosphatase treated (C, F) A-431 whole cell lysates. Antibodies tested include p-EGFR (Tyr 1173): sc-101668 (A, B, C) and EGFR (1005): sc-03 (D, E, F).
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