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p-ATF-2 Antibody (Ser 112/94): sc-101636

 |  Datasheet

(Based on data analysis)

  • p-ATF-2 Antibody (Ser 112/94) is a rabbit polyclonal IgG provided at 100 µg/ml
  • epitope corresponding to phosphorylated Ser 112/94 of ATF-2 of human origin
  • recommended for detection of Ser 112 phosphorylated ATF-2 of human origin and correspondingly phosphorylated Ser 94 of mouse and rat origin by IF and IHC(P)
 

See additional ATF Antibodies including ATF, ATF-1, ATF-2, ATF-3, ATF-5, ATF-5 alpha, ATF-5 beta, ATF-7 and ATF-7IP.

Ordering InformationGene Info
Recommended Support Products:
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IF   IHC(P)   siRNA  
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
p-ATF-2 Antibody (Ser 112/94) sc-101636 100 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
ATF-2 siRNA (h) sc-29205 10 µM $258
ATF-2 siRNA (m) sc-29756 10 µM $258
ATF-2 (h)-PR sc-29205-PR 10 µM, 20 µl $23
ATF-2 (m)-PR sc-29756-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
ATF-2 shRNA Plasmid (h) sc-29205-SH 20 µg $520
ATF-2 shRNA Plasmid (m) sc-29756-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
ATF-2 shRNA (h) Lentiviral Particles sc-29205-V 200 µl $625
ATF-2 shRNA (m) Lentiviral Particles sc-29756-V 200 µl $625
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human ATF2 1386 2q31.1 NM_001880 P15336
 123811
Mouse Atf2 11909 2 C3 P16951
 N/A
 

Eukaryotic gene transcription is regulated by sequence-specific transcription factors which bind modular cis-acting promotor and enhancer elements. The ATF/CREB transcription factor family binds the palindromic cAMP response element (CRE) octanucleotide TGACGTCA. The ATF/CREB family includes CREB-1, CREB-2 (also designated ATF-4), ATF-1, ATF-2 and ATF-3. This family of proteins contain highly divergent N-terminal domains, but share a C-terminal leucine zipper for dimerization and DNA binding. ATF-2 forms homodimers and heterodimers with c-Jun to initiate CRE-dependent transcription. Phosphorylation of ATF-2 at Thr 69 and Thr 71 by stress-activated kinases is necessary for transcriptional activation. Myc also induces phosphorylation of ATF-2 at Thr 69 and Thr 71 to prolong the half-life of ATF-2. ATF-2 also functions as a histone acetyltransferase (HAT) by specifically acetylating histones H2B and H4 in vitro. The gene encoding human ATF-2 maps to chromosome 2q31.1.
p-ATF-2 Antibody (Ser 112/94) Data
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sc-101636
p-ATF-2 (Ser 112/94): sc-101636. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast carcinoma tissue extract showing nuclear staining.
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