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- goat polyclonal IgG, 200 µg/ml
- epitope mapping at the N-terminus of ERCC1 of mouse origin
- recommended for detection of ERCC1 of mouse, rat and, to a lesser extent, human origin by WB, IP, IF and ELISA
- blocking peptide, sc-10157 P
- TransCruz reagent for Gel Supershift and ChIP applications, sc-10157 X, 200 µg/0.1 ml
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ERCC1 Background Information
Xeroderma pigmentosum (XP) is an autosomal recessive disorder characterized by a genetic predisposition to sunlight-induced skin cancer; it is commonly due to deficiencies in DNA repair enzymes. The most frequent mutations are found in the XP genes from group A through G and group V, which encode for nucleotide excision repair proteins. XPF, which is also designated ERCC4 or ERCC11, is a protein that associates directly with the excision repair cross-complementing 1 (ERCC1) factor. ERCC-1, a functional homolog of Rad10 in S. cerevisiae, is a component of a structure-specific endonuclease that is responsible for 5’ incisions during DNA repair. The ERCC1-XPF endo-nuclease preferentially cleaves one strand of DNA between duplex and single-stranded regions near borders of the stem-loop structure and, thereby, contributes to the initial steps of the nucleotide excision repair process.
| ERCC1 (D-16) Product Citations |
See how others have used ERCC1 (D-16): sc-10157 antibody and or ERCC1 (D-16) antibody conjugates.
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ERCC1 (D-16)
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ERCC1 (D-16): sc-10157. Western blot analysis of ERCC1 expression in non-transfected: sc-117752 (A) and human ERCC1 transfected: sc-116554 (B) 293T whole cell lysates. ERCC1 (D-16): sc-10157. Western blot analysis of ERCC1 expression in non-transfected: sc-117752 (A) and mouse ERCC1 transfected: sc-126803 (B) 293T whole cell lysates. |
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