Oct3/4 Antibody (1): sc-101534

Oct-3/4 Antibody (1) is a mouse monoclonal IgG1 antibody that detects Oct-3/4 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Oct-3/4, also known as POU domain, class 5, transcription factor 1, plays a crucial role in maintaining the pluripotency and self-renewal of embryonic stem cells, making Oct-3/4 essential for early development and tissue differentiation. This transcription factor is primarily located in the nucleus, where Oct-3/4 binds to specific DNA sequences to regulate the expression of genes involved in stem cell maintenance and differentiation. Nuclear localization of Oct-3/4 allows for precise control over gene expression during critical developmental stages, influencing lineage commitment and the potential for cells to differentiate into various tissue types. Oct-3/4 has been implicated in tumorigenesis, as dysregulation can lead to uncontrolled cell proliferation, highlighting Oct-3/4′s importance not only in normal development but also in cancer biology. Oct-3/4 exists in two isoforms in humans, which further contribute to the complexity of regulatory functions in stem cells. With an ability to induce rapid proliferation and activate genes such as UTF1, anti-Oct-3/4 antibody (1) serves as a valuable tool for studying Oct-3/4′s role in stem cell biology, early development, and related cellular processes.

The preferred Oct3/4 antibody is Oct3/4 Antibody (C-10): sc-5279.