SerpinB8 (PI-8) Antibody: sc-101371

SerpinB8 Background Information
The serine proteinase inhibitors (serpins) comprise a superfamily of proteins with a diverse set of functions, including the control of blood coagulation, complement activation, programmed cell death and tissue development. SerpinB8 (serpin peptidase inhibitor, clade B (ovalbumin), member 8), also known as P18 or CAP2, is a 374 amino acid protein that localizes to the cytoplasm and belongs to the serine proteinase inhibitor family. Expressed at high levels in lung, liver, heart and skeletal muscle, SerpinB8, which exists as multiple alternatively spliced isoforms, is thought to play a role in platelet aggregation and platelet-regulated pathophysiological responses. The gene encoding SerpinB8 maps to a cluster of Serpin genes on human chromosome 18, which houses over 300 protein-coding genes and contains nearly 76 million bases.