ING3 Background Information ING3 is a nuclear tumor-suppressor protein that has been shown to activate UV-induced apoptosis through a FAS mediated pathway. It has also exhibited the ability to regulate p53 mediated transcription and aptosis, likely by acting as an agent of the NuA4 complex histone acetyltransferase (HAT) complex. Overexpression of ING3 has also shown to increase the cleavage of apoptosis related caspases and BID, however, this is done through a pathway that does not involve increasing mitochondrial proteins. Defects of ING3 lead to a decrease of UV-induced apoptosis and such is believed to greatly affect the prognosis of melanomas and head and neck cancers.
ING3 (162.1)
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ING3 (162.1): sc-101245. Western blot analysis of ING3 expression in PC-12 whole cell lysate.
ING3 (162.1): sc-101245. Immunofluorescence staining of paraformaldehyde-fixed HeLa cells showing nuclear localization.
ING3 (162.1): sc-101245. Western blot analysis of ING3 expression in DU 145 nuclear extract.
