MRE11 (J8-12) Antibody: sc-101233

MRE11 Background Information
Rad52 family members (Rad50, Rad51B/C/D, Rad52, Rad54 and MRE11) mediate DNA double-strand break repair (DSBR) for DNA damage that could otherwise cause cell death, mutation or neoplastic transformation. Rad51 (RECA, BRCC5) interacts with BRCA1 and BRCA2 to influence subcellular localization and cellular response to DNA damage. BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis from deregulation of Rad51. Rad52 forms a heptameric ring that binds single-stranded DNA ends and catalyzes DNA-DNA interaction necessary for the annealing of complementary strands. Rad52 can interact with Rad51. MRE11 (meiotic recombination 11, ATLD, HNGS1) is a nuclear 3' -5' exonuclease/endonuclease that associates with RAD50 and influences homologous recombination, telomere length maintenance, and DNA double-strand break repair. MRE11 is most abundant in proliferating tissues.