CAS Background Information Cellular apoptosis susceptibility protein (CAS), also called Exportin 2, is a 971 amino acid member of the CSE1 family. CAS mediates Importin å re-export from the nucleus to the cytoplasm after import substrates have been released into the nucleoplasm. In the nucleus, CAS binds cooperatively to Importin å and to the GTPase Ran in its GTP-bound (active) form. This complex binds to nucleoporins as it docks to the nuclear pore complex. Once in the cytoplasm, the complex dissociates and Importin å is released and CAS returns to the nuclear compartment and the process begins anew. CAS can be detected highly in proliferating cells. Three isoforms of CAS have been named due to alternative splicing. Isoform 1 is the full length, 971 amino acid protein. Isoform 2 contains an alternative sequence for amino acids 190-195 and is missing amino acids 196-971. Isoform 3 contains an alternative sequence for amino acids 943-945 and is missing amino acids 946-971.
CAS (WW03)
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CAS (WW03): sc-101226. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human colon tissue showing nuclear and cytoplasmic localization.
CAS (WW03): sc-101226. Western blot analysis of CAS expression in MCF7 whole cell lysate.
CAS (WW03): sc-101226. Immunofluorescence staining of paraformaldehyde-fixed HeLa cells showing nuclear localization.
CAS (WW03): sc-101226. Western blot analysis of CAS expression in non-transfected 293T: sc-117752 (A), human CAS transfected 293T: sc-111651 (B) and SW480 (C) whole cell lysates.
CAS (WW03): sc-101226. Western blot analysis of CAS expression in non-transfected: sc-117752 (A) and human CAS transfected: sc-111651 (B) 293T whole cell lysates.
