MAGE-A2 Background Information The melanoma-associated antigen (MAGE) family consists of a number of antigens recognized by cytotoxic T lymphocytes. The MAGE genes were initially isolated from different kinds of tumors and, based on their virtually exclusive tumor-specific expression in adult tissues, they have been used as targets for cancer immunotherapy. MAGE genes encode for tumor-rejection antigens and are expressed in tumors of different histologic types and in normal testis and placenta. MAGE-A2 (melanoma antigen family A2), also known as MAGE2, MAGEA2A, MAGE-A2B or CT1.2 (cancer/testis antigen 1.2), is a 314 amino acid protein that contains one MAGE domain. Expressed in a variety of carcinomas, including melanoma, breast cancer, lung cancer and neck and head squamous cell carcinoma, MAGE-A2/2B is thought to play a role in embryonic development and tumor transformation/progression.
MAGE-A2 (3E5)
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MAGE-A2 (3E5): sc-101221. Western blot analysis of MAGE-A2 expression in Jurkat whole cell lysate.
MAGE-A2 (3E5): sc-101221 Western blot analysis of MAGE-A2 expression in human MAGE-A2 transfected (A) and non-transfected (B) 293T whole cell lysates.
