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home » Transcription Regulators » TSC-22 Antibody / TSC-22 Antibodies » TSC-22 (R5-6): sc-101195

TSC-22 (R5-6) Antibody: sc-101195

  |  Datasheet
  • mouse monoclonal IgG1, 100 µg/ml
  • raised against recombinant TSC-22 of human origin
  • recommended for detection of TSC-22 of human origin by WB, IP, IF, ELISA
 
Additional TSC-22 Antibodies ...
 
Ordering Information
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human TSC22D1 8848 13q14.11 NM_006022, NM_183422 Q15714
 607715
 
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
TSC-22 (R5-6) sc-101195 100 µg/ml $295
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
TSC-22 siRNA (h) sc-44174 10 µM $258
TSC-22 (h)-PR sc-44174-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
TSC-22 shRNA Plasmid (h) sc-44174-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
TSC-22 shRNA (h) Lentiviral Particles sc-44174-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
MCF7 Whole Cell Lysate sc-2206 500 µg/200 µl $104
TSC-22 (h): 293 Lysate sc-112912 100µg/200µl $205

TSC-22 Background Information
Transforming growth factor-beta-stimulated clone-22 (TSC-22) acts as a transcriptional regulator to modulate cell growth and differentiation and cell death. TSC-22 contains a leucine zipper domain as well as a nuclear export signal, resulting in cytoplasmic localization in living cells. However, concomitant with the induction of apoptosis, TSC-22 translocates from the cytoplasm to the nucleus and shows transcriptional regulatory activity. TSC-22 acts as a major downstream component in the TGF-beta pathway, and also the PPAR© signalling pathway. The association of these two pathways with tumor suppression, and the significant downregulation of TSC-22 mRNA in various cancer types, such as brain and salivary gland tumors, imply an antiproliferative role for TSC-22.
TSC-22 (R5-6)
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sc-101195
TSC-22 (R5-6): sc-101195. Western blot analysis of TSC-22 expression in MCF7 whole cell lysate.
sc-101195
TSC-22 (R5-6): sc-101195. Immunofluorescence staining of paraformaldehyde-fixed HeLa cells showing nuclear and cytoplasmic localization.
sc-101195
TSC-22 (R5-6): sc-101195. Western blot analysis of TSC-22 expression in non-transfected: sc-110760 (A) and human TSC-22 transfected: sc-112912 (B) 293 whole cell lysates.
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