RUNX1 (DW71) Antibody: sc-101146

RUNX1 Background Information
The mammalian Runt-related transcription factor (RUNX) family comprises three members, RUNX1 (also designated AML-1, PEBP2åB, CBFA2), RUNX2 (also designated AML-3, PEBP2åA, CBFA1, Osf2) and RUNX3 (also designated AML-2, PEBPåC, CBFA3). RUNX family members are DNA-binding proteins that regulate the expression of genes involved in cellular differentiation and cell cycle progression. RUNX1 is involved in hematopoiesis and is frequently targeted in human leukemia by chromosomal translocations that fuse the DNA-binding domain of RUNX1 to other transcription factors and corepressor molecules. In addition to its role in leukemogenesis, RUNX1 is also involved in sensory neuron diversification. Specifically, RUNX1 promotes axonal growth, is selectively expressed in neural crest-derived TrkA+ sensory neurons and mediates TrkA transactivation in migratory neural crest cells. Alternative splicing gives rise to several isoforms of RUNX1.