XAB1 (38.1-H) Antibody: sc-101142

XAB1 Background Information
XAB1 (XPA binding protein 1), also known as MBDIN, NTPBP, ATPBD1A or HUSSY-23, is a 374 amino acid cytoplasmic protein that is involved in protein synthesis events. Expressed ubiquitously with highest expression in testis, XAB1 binds to the RNA polymerase II- (Poll II) associated proteins RPAP1-3 and to XPA (a protein involved in DNA repair mechanisms), thereby forming an interface with Poll II. Via this interaction, XAB1 is thought to mediate the involvement of Pol II in both protein complex formation and protein chaperone/scaffolding activities. In addition, XAB1 interacts with components of the integrator and molecular chaperone complexes, further implicating XAB1 in protein assembly. XAB1 contains a cluster of acidic amino acids in its C-terminal region and a series of sequences similar to those found in GTP-binding proteins in its N-terminal region, suggesting that XAB1 has possible GTPase activity.