GlnRS (X-12) Antibody: sc-100988

GlnRS Background Information
Aminoacyl-tRNA synthetases function to catalyze the aminoacylation of tRNAs by their corresponding amino acids, thus linking amino acids with tRNA-contained nucleotide triplets. GlnRS (Glutaminyl-tRNA synthetase), also known as QARS, is a 775 amino acid member of the class-I aminoacyl-tRNA synthetase family. Localized to the cytoplasm, GlnRS is part of a multi-protein complex composed of nine aminoacyl-tRNA synthetases that are specific for nine amino acids, namely Arg, Asp, Glu, Gln, Ile, Leu, Lys, Met and Pro. In this complex, GlnRS functions to catalyze the ATP-dependent conversion of L-glutamine (Gln) and tRNA(Gln) to Gln-tRNA(Gln). While GlnRS is used to synthesize Gln-tRNA(Gln) in many eukaryotic cells, prokaryotes and organelles, such as mitochondria and chloroplasts, can synthesize Gln-tRNA(Gln) in a two step process involving misacylation and amidation reactions.