BAF Background Information Barrier-to-autointegration factor (BAF) binds non-specifically to double stranded DNA, possibly to play a role in tissue- or cell type-specific gene expression by interacting with different homeodomain transcription factors. BAF compresses chromatin structure and interacts with the LEM domain of nuclear proteins to play a crucial role in membrane recruitment and chromatin decondensation during nuclear assembly. Additionally, retroviruses like HIV-1 incorporate BAF from host cells into preintegration complexes (PICs) to prevent autointegration of retroviral DNA and thereby promote integration of retroviral DNA into the host chromosome.
BAF (ZZ-52)
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BAF (ZZ-52): sc-100978. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human esophagus tissue showing nuclear localization.
BAF (ZZ-52): sc-100978. Western blot analysis of BAF expression in Jurkat whole cell lysate.
