transgelin-3 Background Information Transgelin (also designated SM22å) is expressed abundantly in smooth muscle cells. Transgelin-2 (also known as SM22å homolog) is a homolog of transgelin and is also expressed in smooth muscle cells and by peritoneal B-1 cells. Unlike the other two transgelin proteins, transgelin-3 (also designated TAGLN2, NP22 (neuronal protein 22) or NP25) is predominantly expressed in brain. Transgelin-3 contains a putative Actin-binding domain, two EF-hand motifs, two potential phosphorylation sites and a calponin-homology (CH) domain. Transgelin-3 shares homology with transgelin and Calponin, two cytoskeleton-interacting proteins. Belonging to the calponin family, transgelin-3 colocalizes with Actin and Tubulin, suggesting a possible role for transgelin-3 in neuronal plasticity or as a signaling protein. Due to a varied expression pattern, transgelin-3 may play different roles in the developing and adult brain. Expression of transgelin-3 is upregulated in regions of the human alcoholic brain.
transgelin-3 (438.1)
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transgelin-3 (438.1): sc-100960. Western blot analysis of transgelin-3 expression in non-transfected 293: sc-110760 (A), human transgelin-3 transfected 293: sc-112764 (B) and IMR-32 (C) whole cell lysates.
