DAAM1 (WW-3) Antibody: sc-100942

DAAM1 Background Information
DAAM1 (dishevelled associated activator of morphogenesis 1) is a 1,078 amino acid member of the Formin homology protein family. Localized to the perinuclear cytoplasm and expressed throughout the body, DAAM1 binds to disheveled (Dvl) and Rho and mediates the Wnt-induced formation of the Dvl-Rho complex. Once complexed to Dvl, Rho becomes activated and can regulate cell polarity, movement and cytoskeletal architecture. Activation of Rho is dependent upon formation of the Dvl-Rho complex. This suggests that DAAM1 (which is required for complex formation) is a critical component of cellular cortex functions. DAAM1 contains several binding domains which allow it to interact with various proteins such as CIP4, FNBP1 and spectrin, thereby helping to coordinate the dynamics of the actin filament system. Additionally, DAAM1 is thought to act as a scaffolding protein by recruiting Rho-GEF and Rho-GDP, thus enhancing Rho-GTP formation. Three distinct isoforms exist due to alternative splicing events.