TES Background Information TES was originally identified as a candidate tumour suppressor gene and has been found to encode a novel focal adhesion protein called TES or Testin. TES localizes to cell-cell contacts, Actin stress fiber and interacts with a variety of cytoskeletal proteins including Zyxin, Mena, VASP, Talin and Actin. The ability of TES to associate with a-actinin, paxillin and Zyxin is dependent on the conformational state of the molecule. TES contains 3 LIM zinc-binding domains and may act as a tumor suppressor. Overexpression of the TES gene results in increased cell spreading and decreased cell motility.
TES (AA-7)
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TES (AA-7): sc-100914. Western blot analysis of TES expression in non-transfected: sc-117752 (A) and mouse TES transfected: sc-123982 (B) 293T whole cell lysates.
TES (AA-7): sc-100914. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human tonsil tissue showing cytoplasmic localization.
TES (AA-7): sc-100914. Immunofluorescence staining of paraformaldehyde-fixed HeLa cells showing cytoplasmic localization.
TES (AA-7): sc-100914. Western blot analysis of TES expression in non-transfected: sc-117752 (A) and mouse TES transfected: sc-123983 (B) 293T whole cell lysates.
TES (AA-7): sc-100914. Western blot analysis of TES expression in non-transfected 293T: sc-117752 (A), human TES transfected 293T: sc-170329 (B) and K-562 (C) whole cell lysates.
