TARDBP Background Information TARDBP (TAR DNA binding protein), also known as TDP-43, is a nuclear protein that contains two RRM (RNA recognition motif) domains. Ubiquitously expressed with highest levels found in placenta, lung, pancreas, spleen and genital tract, TARDBP functions as an DNA-binding protein and specifically binds to the TAR DNA sequence motifs of HIV. Via this association with TAR motifs, TARDBP acts as a transcriptional repressor and inhibits HIV-1 transcription. TARDBP can also function as a negative regulator of splicing activity and is known to be involved in the splicing of CFTR (cystic fibrosis transmembrane receptor). In addition, TARDBP is a major component of ubiquitin-positive inclusion bodies that are prominent in many neurodegenerative diseases. This suggests that TARDBP may play a role in the development of neurodegenerative disorders. Due to alternative splicing events, various isoforms exist for TARDBP.
TARDBP (41-7.1)
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TARDBP (41-7.1): sc-100871. Western blot analysis of TARDBP expression in A-431 whole cell lysate.
TARDBP (41-7.1): sc-100871. Immunofluorescence staining of paraformaldehyde-fixed HeLa cells showing nuclear localization.
TARDBP (41-7.1): sc-100871. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human leiomyosarcoma tissue showing nuclear localization.
TARDBP (41-7.1): sc-100871. Western blot analysis of TARDBP expression in non-transfected: sc-117752 (A) and human TARDBP transfected: sc-111497 (B) 293T whole cell lysates.
TARDBP (41-7.1): sc-100871. Western blot analysis of TARDBP expression in non-transfected: sc-117752 (A) and human TARDBP transfected: sc-129918 (B) 293T whole cell lysates.
