epitope mapping at the C-terminus of DAPK2 of human origin
recommended for detection of DAPK2 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine and canine
DAPK2 Background Information Death-associated protein kinase 2 (DAPK2), also designated death-associated protein kinase-related protein-1 (DRP-1), is a calcium/calmodulin-regulated serine/threonine kinase that binds to calmodulin, undergoes autophosphorylation in response to an increase in cellular calcium concentration, and phosphorylated myosin light chain (MLC) as an exogenous substrate. DAPK2 is expressed in heart, lung, and skeletal muscle and is localized to the cytoplasm. DAPK2 displays significant homology to DAP-kinase, which mediates interferon (IFN)-g-induced apoptosis in HeLa. Subsequently, DAPK2 is thought to function as a possible tumor suppressor gene.
