Ribosomal Protein S19 Antibody (WW-4): sc-100836

Ribosomal Protein S19 Antibody (WW-4) is a mouse monoclonal IgG2b kappa light chain antibody that detects Ribosomal Protein S19 (RPS19) of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-RPS19 antibody (WW-4) is available as the non-conjugated format. RPS19 is a crucial component of the 40S ribosomal subunit, playing a significant role in the assembly and function of ribosomes, which are essential for protein synthesis in all living cells. RPS19 is located primarily in the nucleolus, where RPS19 is involved in the biogenesis of ribosomes, and proper localization is vital for efficient ribosome production. Deficiencies in RPS19 can lead to impaired ribosome assembly, which affects cellular protein synthesis and can result in severe consequences such as Diamond-Blackfan anemia, a condition characterized by a failure to produce red blood cells.

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Ribosomal Protein S19 Antibody (WW-4) References:

1. Truncated and dispersed rpl2 and rps19 pseudogenes are co-transcribed with neighbouring downstream genes in wheat mitochondria.  |  Subramanian, S., et al. 2001. Curr Genet. 39: 264-72. PMID: 11453256
2. Nucleolar localization of RPS19 protein in normal cells and mislocalization due to mutations in the nucleolar localization signals in 2 Diamond-Blackfan anemia patients: potential insights into pathophysiology.  |  Da Costa, L., et al. 2003. Blood. 101: 5039-45. PMID: 12586610
3. Gene symbol: RPS19. Disease: Diamond-Blackfan anaemia.  |  Gonçalves, P., et al. 2004. Hum Genet. 115: 534. PMID: 15678589
4. Fate of mitochondrially located S19 ribosomal protein genes after transfer of a functional copy to the nucleus in cereals.  |  Fallahi, M., et al. 2005. Mol Genet Genomics. 273: 76-83. PMID: 15711972
5. Agonist and antagonist dual effect of the cross-linked S19 ribosomal protein dimer in the C5a receptor-mediated respiratory burst reaction of phagocytic leukocytes.  |  Revollo, I., et al. 2005. Inflamm Res. 54: 82-90. PMID: 15750715
6. An RNA interference model of RPS19 deficiency in Diamond-Blackfan anemia recapitulates defective hematopoiesis and rescue by dexamethasone: identification of dexamethasone-responsive genes by microarray.  |  Ebert, BL., et al. 2005. Blood. 105: 4620-6. PMID: 15755903
7. Development of cellular models for ribosomal protein S19 (RPS19)-deficient diamond-blackfan anemia using inducible expression of siRNA against RPS19.  |  Miyake, K., et al. 2005. Mol Ther. 11: 627-37. PMID: 15771965
8. Reduced gene expression of clustered ribosomal proteins in Diamond-Blackfan anemia patients without RPS19 gene mutations.  |  Koga, Y., et al. 2006. J Pediatr Hematol Oncol. 28: 355-61. PMID: 16794503
9. Analysis of the interactome of ribosomal protein S19 mutants.  |  Caterino, M., et al. 2014. Proteomics. 14: 2286-96. PMID: 25069755
10. The roles of ribosomal protein S19 C-terminus in a shortened neutrophil lifespan through delta lactoferrin.  |  Nishiura, H., et al. 2015. Immunobiology. 220: 1085-92. PMID: 26003841
11. Depletion of ribosomal protein S19 causes a reduction of rRNA synthesis.  |  Juli, G., et al. 2016. Sci Rep. 6: 35026. PMID: 27734913
12. The roles of a ribosomal protein S19 polymer in a mouse model of carrageenan-induced acute pleurisy.  |  Yamanegi, K., et al. 2017. Immunobiology. 222: 738-750. PMID: 28190533

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Ribosomal Protein S19 Antibody (WW-4) has 18 citations in a variety of scientific publications.

Primary antibodies like Anti-Ribosomal Protein S19 Antibody (WW-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Ribosomal Protein S19 Antibody (WW-4) Specifications

Alternate Product Name: Ribosomal Protein S19

Product Clone Name: WW-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 1-146

Epitope Target: Ribosomal Protein S19

Epitope Species: human

Product Reactivity/Detection: Ribosomal Protein S19

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 18 citations in various scientific publications

Available Conjugates/Forms for Ribosomal Protein S19 Antibody (WW-4): N/A