 |
- goat polyclonal IgG, 200 µg/ml
- epitope mapping at the C-terminus of ATRX of human origin
- recommended for detection of ATRX of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine and porcine
- blocking peptide, sc-10080 P
|
|
| |
Ordering InformationProduct Citations
Recommended Support Products:
(click button of application of choice)
ATRX Background Information
ATRX is a member of the SNF2 family of helicase/ATPases, which contribute to the remodeling of the nucelosome structure in an ATP-dependent manner, and facilitate the initiation of transcription and replication. Structurally, ATRX contains a PHD zinc finger motif. ATRX is regulated throughout the cell cycle where it is differentially distributed within the nucleus. During interphase, ATRX predominately associates with the nuclear matrix, while during mitosis, ATRX localizes with condensed chromatin. At the onset of M phase, phosphorylation rapidly induces this redistribution of ATRX to the short arms of human acrocentric chromosomes, where it then specifically complexes with heterochromatin protein 1 å to mediate chromosomal segregation. Mutations in the ATRX gene correlate with a high incidence of severe X-linked form of syndromal mental retardation associated with å thalassaemia or ATR-X syndrome.
| ATRX (C-16) Product Citations |
See how others have used ATRX (C-16): sc-10080 antibody and or ATRX (C-16) antibody conjugates.
3 total citations Loading citations.
|
| |
|
|
|
ATRX (C-16)
Click on image to enlarge
|
|
ATRX (C-16): sc-10080. Western blot analysis of ATRX expression in HeLa nuclear extract.
ATRX (C-16): sc-10080. Western blot analysis of human recombinant ATRX fusion protein.
ATRX (C-16): sc-10080. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.
|
|
Download
|
|
